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Endocrine glands have _____ to carry their secretions to the specific organ.
(c) Endocrine glands lack ducts and pass their secretions into the surrounding blood for transport to the site of action. They are also called the ductless glands.
Which of the following statements regarding hormones is incorrect?
(c) Hormones do not provide energy or building materials but they affect growth, differentiation and metabolic activities of their target cell.
Enzymes, vitamins and hormones can be classified into a single category of biological chemicals, because all of these
Thousands of biomolecules are involved in diverse biological processes in living beings.
Vitamins, hormones, enzymes, ATP, carbs, lipids, nucleic acids, and proteins are only a few examples.
The key macromolecules that play a critical part in biological systems and are primarily responsible for practically all biochemical activities include carbohydrates, proteins, lipids, and nucleic acid.
The metabolic operations of living entities such as plants and animals are aided by biological molecules or biomolecules.
The majority of biomolecules in live cells serve a variety of purposes, including:
1. They are necessary for cellular and body structure.
2. During cellular respiration, they serve as energy-rich fuels.
3. Molecules are utilized to transmit information about how to govern the development and biological traits from one generation to the next.
4. They are effective catalytic agents for a variety of chemical reactions that occur in cells and living organisms.
Hence, enzymes, vitamins, and hormones can be classified as a single category of biological chemicals, as they help in regulating metabolism.
Which one of the following statements is correct?
(c) Endocrine system, like the nervous system, is meant for internal communication and regulation of the animal body. These two systems operate in a coordinated way on many occasions. Many important functions of the endocrine system are in fact, under the control of nervous system. Therefore, the two systems are often collectively called as neuroendocrine system.
Secretion of which of the following is under control of neurosecretory nerve cells?
(c) The neurosecretory cells of the hypothalamus secrete releasing factors (neurohormones) that regulate the secretion of hormones from the anterior pituitary.
The given figure shows main endocrine glands in human body. Identify A to E and select the correct option.
\(
\begin{array}{|c|c|c|c|c|c|}
\hline & A & B & C & D & \text { E } \\
\hline \text { (a) } & \text { Pineal } & \text { Pituitary } & \text { Thyroid and parathyroid } & \text { Thymus } & \text { Adrenal } \\
\hline \text { (b) } & \text { Pituitary } & \text { Pineal } & \text { Thyroid and parathyroid } & \text { Adrenal } & \text { Thymus } \\
\hline \text { (c) } & \text { Pituitary } & \text { Pineal } & \text { Thyroid and parathyroid } & \text { Thymus } & \text { Kidney } \\
\hline \text { (d) } & \text { Pituitary } & \text { Pineal } & \text { Thyroid and parathyroid } & \text { Thymus } & \text { Adrenal } \\
\hline
\end{array}
\)
What is the effect of GnRH produced by hypothalamus?
(a) Gonadotropin releasing hormone \((\mathrm{G} n \mathrm{RH})\), stimulates the anterior lobe of pituitary gland (adenohypophysis) to secrete two gonadotropins, FSH and LH. In males LH stimulates the Leydig’s cells of the testis to secrete androgens.
Select the option that correctly identifies the labels A, B, C and D in the given diagram.
\(
\begin{array}{|c|c|c|c|c|}
\hline & A & B & C & D \\
\hline \text { (a) } & \text { Anterior pituitary } & \begin{array}{l}
\text { Posterior } \\
\text { pituitary }
\end{array} & \text { Blood vessels } & \text { Thalamus } \\
\hline \text { (b) } & \text { Posterior pituitary } & \begin{array}{l}
\text { Anterior } \\
\text { pituitary }
\end{array} & \text { Hypothalamus } & \text { Thalamus } \\
\hline \text { (c) } & \text { Anterior pituitary } & \begin{array}{l}
\text { Posterior } \\
\text { pituitary }
\end{array} & \text { Portal circulation } & \begin{array}{l}
\text { Hypothalamic } \\
\text { neurons }
\end{array} \\
\hline \text { (d) } & \text { Hypothalamic } & \begin{array}{l}
\text { Posterior } \\
\text { pituitary }
\end{array} & \text { Anterior pituitary } & \text { Portal circulation } \\
\hline
\end{array}
\)
TSH (thyroid stimulating hormone) is produced by
(c) Thyroid stimulating hormone (TSH) is produced by the anterior lobe of the pituitary and it stimulates the production and secretion of thyroid hormones.
Adrenocorticotropic hormone is secreted by
(d) Adrenocorticotropic hormone is secreted by anterior pituitary. This hormone stimulates adrenal cortex to secrete its hormones.
MSH is secreted by
(b) Middle lobe of pituitary secretes MSH (melanocyte stimulating hormone) that controls the synthesis of melanin granules in the chromatophores.
FSH is secreted by
FSH (Follicle stimulating hormone) is produced by basophilic cells of anterior lobe of pituitary gland.
In females, it stimulates growth of ovarian follicles until ovulation occurs.
In males, it stimulates development of seminiferous tubules and spermatogenesis i.e. formation of sperms from germ cells.
So, the correct answer is ‘Anterior lobe of pituitary’.
Which of the following statements about ‘neurohypophysis’ is correct?
(c) Neurohypophysis or the posterior lobe of pituitary gland consists of axonal endings of neurosecretory neurons located in hypothalamus. Oxytocin and vasopressin are the hormones secreted by hypothalamus but stored and released by neurohypophysis.
Identify A, B, C and D in the given flow chart and select the correct option.
\(
\begin{array}{|c|c|c|c|c|}
\hline & A & B & C & D \\
\hline \text { (a) } & \text { Neurohypophysis } & \text { Adenohypophysis } & \text { Pars distalis } & \text { Pars intermedia } \\
\hline \text { (b) } & \text { Adenohypophysis } & \text { Neurohypophysis } & \text { Pars intermedia } & \text { Pars distalis } \\
\hline \text { (c) } & \text { Adenohypophysis } & \text { Neurohypophysis } & \text { Pars distalis } & \text { Pars intermedia } \\
\hline \text { (d) } & \text { Neurohypophysis } & \text { Adenohypophysis } & \text { Pars intermedia } & \text { Pars distalis } \\
\hline
\end{array}
\)
With reference to the pituitary, which of the following statements is correct?
(c) Neurohypophysis or the posterior lobe of pituitary gland consists of axonal endings of neurosecretory neurons located in hypothalamus. Oxytocin and vasopressin are the hormones secreted by hypothalamus but stored and released by neurohypophysis.
Pituicytes are under the control of
(c) Pituicytes are the cells found in the posterior lobe of pituitary gland. The hormones, oxytocin and vasopressin released by pituicytes are actually produced by hypothalamus.
Which of the following hormones does not have a particular target organ in the body?
(a) Growth hormone secreted by the anterior pituitary has a widespread effect on the body. It stimulates growth of various body cells, promotes protein anabolism, absorption of calcium from bowel and conversion of glycogen to glucose.
Which hormone stimulates the secretion of milk from female?
(d) Prolactin hormone secreted by the anterior lobe of pituitary stimulates the secretion of milk in females.
Identify from the following, a hormone produced by the pituitary gland in both males and females but functional only in females.
(b) Prolactin is a hormone secreted by the pituitary gland. It is functional only in females – the development of breasts and initiation of lactation.
So, the correct answer is ‘Prolactin’
Excess secretion of growth hormone in adults leads to ______.
The gonadotropic hormones are secreted by
Explanation of the correct option:
1. Gonadotropic hormones are secreted by the anterior pituitary.
2. These hormones act on the gonads i.e. ovaries and testes.
3. Gonadotropin-releasing hormones which are secreted by the hypothalamus act on the pituitary gland and stimulate it to synthesize and secrete gonadotropins.
4. The two primary gonadotropins released are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
LH and FSH are collectively called
(b) Gonadotropin releasing hormone (GnRH), stimulates the anterior lobe of pituitary gland (adenohypophysis) to secrete two gonadotropins, FSH and LH. In males LH stimulates the Leydig’s cells of the testis to secrete androgens.
Sertoli cells are regulated by the pituitary hormone known as
(c) Sertoli cells are regulated by FSH secreted by the anterior pituitary.
Ovulation in females is under the control of
(b) Ovulation in females is under the control of luteinising hormone (LH), secreted by the anterior pituitary gland. It also stimulates development of corpus luteum.
Secretion of progesterone by corpus luteum is initiated by
(d) Luteinising hormone (LH) secreted by the anterior lobe of pituitary gland stimulates corpus luteum of the ovary to secrete progesterone.
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|l|l|r|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { FSH } & \text { (i) } & \begin{array}{l}
\text { Transported axonally to } \\
\text { neurohypophysis from } \\
\text { hypothalamus }
\end{array} \\
\hline \text { B. } & \text { MSH } & \text { (ii) } & \begin{array}{l}
\text { Acts on melanocytes and } \\
\text { regulates pigmentation of } \\
\text { skin }
\end{array} \\
\hline \text { C. } & \text { Vasopressin (ADH) } & \text { (iii) } & \begin{array}{l}
\text { Stimulates the growth and } \\
\text { development of ovarian } \\
\text { follicles in female }
\end{array} \\
\hline \text { D. } & \text { Pars intermedia } & \text { (iv) } & \begin{array}{l}
\text { In human, it is almost } \\
\text { merged with pars distalis }
\end{array} \\
\hline
\end{array}
\)
The function of oxytocin is to help in
(a) Oxytocin, secreted by the posterior pituitary gland causes contraction of smooth muscles of the uterus during child birth.
Diabetes insipidus occurs due to the hyposecretion of
(d) Vasopressin (antidiuretic hormone, ADH) released from posterior pituitary increases reabsorption of water from distal and collecting tubules of the kidney, thus, helping in producing concentrated urine. If there is hyposecretion of vasopressin, then water will not be reabsorbed from the tubules and the urine thus produced will be dilute. This disorder is called diabetes insipidus which is characterised by producing dilute urine several times a day.
The hormone, which is related to the urine concentration in mammals, is
(a) Vasopressin (antidiuretic hormone, ADH) released from posterior pituitary increases reabsorption of water from distal and collecting tubules of the kidney, thus, helping in producing concentrated urine. If there is hyposecretion of vasopressin, then water will not be reabsorbed from the tubules and the urine thus produced will be dilute. This disorder is called diabetes insipidus which is characterised by producing dilute urine several times a day.
ADH
(a) Antidiuretic hormone (ADH) stimulates reabsorption of water and electrolytes by the distal tubules and thereby reduces loss of water through urine.
Melatonin is secreted by
The function of pineal body is to
(d) Pineal body is a very small, reddish-grey, vascular, conical, solid body located in the brain. It secretes a hormone named melatonin. Melatonin makes the skin colour lighter in certain animals and also regulates the functioning of gonads, thus, controls sexual behaviour and regulates the period of puberty.
Observe the given figures and select the option that correctly identifies the labels A, B, C and D.
\(
\begin{array}{|l|l|l|l|l|}
\hline & A & B & C & D \\
\hline \text { (a) } & \text { Parathyroid gland } & \text { Isthmus } & \text { Trachea } & \text { Thyroid gland } \\
\hline \text { (b) } & \text { Thyroid gland } & \text { Isthmus } & \text { Trachea } & \text { Parathyroid gland } \\
\hline \text { (c) } & \text { Thyroid gland } & \text { Isthmus } & \text { Larynx } & \text { Parathyroid gland } \\
\hline \text { (d) } & \text { Thyroid gland } & \text { Corpus luteum } & \text { Trachea } & \text { Parathyroid gland } \\
\hline
\end{array}
\)
Which one of the following endocrine glands stores its secretion in the extracellular space before discharging it into the blood?
(b) Thyroid gland stores its hormones in the colloid. Colloid is a homogenous material present in the thyroid follicles of thyroid gland.
Goitre is a pathological condition associated with
(c) Goitre is caused due to the deficiency of iodine in the diet. lodine is needed for the synthesis of thyroxine secreted by thyroid gland. The production of this hormone decreases with poor iodine diet. This causes enlargement of thyroid gland which is called goitre.
Exophthalmic goitre is also called
Explanation:
(c) Exophthalmic goiter is also known as Grave’s disease or toxic diffuse goiter. The exophthalmic disease is an endocrine disorder which is caused by the hypersecretion of thyroid hormone (thyroxine), known as hyperthyroidism and also caused by the extra response of thyroid hormone in the tissue, this condition is called thyrotoxicosis. It is an autoimmune disease. The sign of this disease is fast heartbeats, nervousness, etc.
The hormone which regulates the basal metabolism in our body is secreted from
(d) Thyroid hormones, thyroxine and tri-iodothyronine regulate the basal metabolism of our body.
What is the function of calcitonin?
(b) Calcitonin is a hormone secreted by the thyroid gland. It lowers the calcium level in the blood by suppressing the release of calcium ions from the bones.
Which hormone promotes cell division, protein synthesis and bone growth?
(d) Growth hormone (GH) secreted by anterior pituitary promotes cell division, protein synthesis and bone growth.
Which of the following statements is correct for ‘parathormone’?
The parathyroid gland produce parathyroid hormone. This hormone helps maintain an appropriate balance of calcium in the blood stream and in tissues that depend on calcium for proper functioning. So, option a is the correct option.
The blood calcium level is lowered by the deficiency of
(c) The hormone whose deficiency leads to lowered blood calcium level in blood is secreted by the chief cells of the parathyroid gland which is located in close association with the thyroid gland. A parathyroid gland is a group of four small glands.
\(\mathrm{Ca}^{2+}\) level in body is controlled by
(d) \(\mathrm{Ca}^{2+}\) level in the body is controlled by both thyroid gland and parathyroid gland. Thyroid gland secretes a hormone, thyrocalcitonin which checks the excess blood calcium levels. Parathyroid gland secretes hormone called parathyroid hormone or parathormone which increases the \(\mathrm{Ca}^{2+}\) levels in the blood.
A person is having problem with calcium and phosphorus metabolism in his body. Which one of the following glands may not be functioning properly?
(d) Parathyroid glands located behind the thyroid gland, produce a hormone called parathormone. This hormone maintains calcium and phosphorus balance in the body. Thus, if a person is having problem with calcium and phosphorus metabolism in the body, this means, his parathyroid glands are not functioning properly.
Increase in bleeding time and delay in blood coagulation is due to the deficiency of which hormone?
(c) Calcium plays an important role in blood clotting. Parathormone, a hormone released by parathyroid glands, increases calcium level in the blood. Therefore, deficiency of this hormone will decrease $\mathrm{Ca}^{2+}$ level in blood, thus leading to delay in blood clotting and increase in bleeding time.
Which gland atrophies in adults?
(b) Thymus gland is a prominent gland at birth but gradually atrophies in the adult, therefore, it is called temporary gland. It secretes a hormone thymosin which is involved in producing immunity.
Which one of the following is termed temporary gland?
(b) Thymus gland is a prominent gland at birth but gradually atrophies in the adult, therefore, it is called temporary gland. It secretes a hormone thymosin which is involved in producing immunity.
Adrenals are located above
(d) Our body has one pair of adrenal glands, one each at the anterior end of both kidneys.
Identify the parts labelled A, B and C in the given figure and select the correct option (second figure is the cross section of ‘ A ‘).
\(
\begin{array}{|l|l|l|l|}
\hline & A & B & C \\
\hline \text { (a) } & \text { Adrenal gland } & \text { Cortex } & \text { Medulla } \\
\hline \text { (b) } & J G A & \text { Cortex } & \text { Medulla } \\
\hline \text { (c) } & \text { Adrenal gland } & \text { Medulla } & \text { Cortex } \\
\hline \text { (d) } & \text { Adrenal gland } & \text { Pars distalis } & \text { Pars intermedia } \\
\hline
\end{array}
\)
Underproduction of hormones by adrenal cortex causes _______.
Feeling the tremors of an earthquake, a scared resident of seventh floor of a multistoreyed building starts climbing down the stairs rapidly. Which hormone initiated this action?
Adrenaline, also known as adrenaline or epinephrine, is a hormone, neurotransmitter, and medication. Epinephrine is normally produced by both the adrenal glands and certain neurons. It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart, pupil dilation response, and blood sugar level. It does this by binding to alpha and beta receptors. It is found in many animals and some single-cell organisms.
So the correct option is ‘Adrenaline’.
Which hormone causes dilation of blood vessels, increased oxygen consumption and glucogenesis?
(d) Adrenaline (Epinephrine) hormone is secreted by adrenal medulla under the conditions of emergency. Therefore, it is also known as emergency hormone. During emergency, it is released and causes dilation of blood vessels, so that the blood flow is increased. It also increases heart beat so that more oxygen is consumed and it also increases blood glucose level.
Adrenaline directly affects
(a) Adrenaline prepares the body for emergency reactions like fight and flight. Therefore, it directly affects the SA node to increase the rate of heart beat.
Which of the following is called emergency gland of the body?
(b) Adrenaline (Epinephrine) hormone is secreted by adrenal medulla under the conditions of emergency. Therefore, it is also known as emergency hormone. During emergency, it is released and causes dilation of blood vessels, so that the blood flow is increased. It also increases heart beat so that more oxygen is consumed and it also increases blood glucose level.
Which of the following is a mineralocorticoid?
(d) Aldosterone is a major mineralocorticoid, secreted by adrenal cortex. It regulates mineral metabolism and stimulates the reabsorption of \(\mathrm{Na}^{+}\)and water and excretion of \(\mathrm{K}^{+}\)and phosphate ions. Therefore, it is called salt-retaining hormone.
Reabsorption of \(\mathrm{Na}^{+}\)is controlled by which one of the following hormones?
(a) Aldosterone is a major mineralocorticoid, secreted by adrenal cortex. It regulates mineral metabolism and stimulates the reabsorption of \(\mathrm{Na}^{+}\)and water and excretion of \(\mathrm{K}^{+}\)and phosphate ions. Therefore, it is called salt-retaining hormone.
In which of the following options, hormone is not matching with its source and function?
\(
\begin{array}{|c|c|c|c|}
\hline & \text { Hormone } & \text { Source } & \text { Function } \\
\hline \text { (a) } & \text { Glucocorticoids } & \text { Adrenal Cortex } & \begin{array}{l}
\text { Produces anti inflammatory } \\
\text { reactions }
\end{array} \\
\hline \text { (b) } & \text { Vasopressin } & \begin{array}{l}
\text { Posterior } \\
\text { pituitary }
\end{array} & \begin{array}{l}
\text { Stimulates resorption of water and } \\
\text { electrolytes }
\end{array} \\
\hline \text { (c) } & \begin{array}{l}
\text { Parathyroid } \\
\text { hormone }
\end{array} & \text { Thyroid } & \text { Decreases the blood } \mathrm{Ca}^{2+} \text { level } \\
\hline \text { (d) } & \text { Melatonin } & \text { Pineal gland } & \text { Maintains sleep-wake cycle } \\
\hline
\end{array}
\)
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|l|l|c|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { Thyroid } & \text { (i) } & \text { Acts on the renal tubules } \\
\hline \text { B. } & \text { Adrenal } & \text { (ii) } & \text { Regulates blood calcium level } \\
\hline \text { C. } & \text { Pituitary } & \text { (iii) } & \begin{array}{l}
\text { Maintains diurnal rhythm of } \\
\text { our body }
\end{array} \\
\hline \text { D. } & \text { Pineal } & \text { (iv) } & \text { Acts on the melanocytes } \\
\hline
\end{array}
\)
Besides corticotropin releasing hormone \((\mathrm{CRH})\), which other hormone also stimulates the release of adrenocorticotropic hormone (ACTH)?
(d) Feedback control is a mechanism by which secretion of hormones is under the control of factors or other hormones. When the level of epinephrine decreases in the blood, it stimulates the hypothalamus to secrete more CRH which results in increased production of ACTH from anterior lobe of pituitary which in turn stimulates the increased production of epinephrine from adrenal medulla.
The islets of Langerhans are found in
Islets of Langerhans are produced in the pancreas. It is of four types of cells- alpha cells that ooze glucagon, \(\beta\) cells that secrete insulin, delta cells that secrete somatostatin, and F cells that exude pancreatic polypeptide.
Islets of Langerhans, also known as islands of Langerhans, unevenly shaped patches of endocrine tissue located inside the pancreas of most vertebrates.
Insulin is secreted by _____ of the pancreas.
The source of somatostatin is same as that of
(b) Insulin, glucagon and somatostatin are secreted by islets of Langerhans of the pancreas. Somatostatin suppresses the release of other hormones from the pancreas.
Which of the following match is correct?
\(
\begin{array}{|l|l|l|}
\hline & \text { Hormone } & \text { Effect } \\
\hline \text { (a) } & \text { Oxytocin } & \text { Milk ejection hormone } \\
\hline \text { (b) } & \text { Glucagon } & \text { Decreases blood sugar level } \\
\hline \text { (c) } & \text { Adrenaline } & \text { Decreases heart rate } \\
\hline \text { (d) } & \text { None of these } & \\
\hline
\end{array}
\)
(a) Glucagon – Increases blood sugar level ; Adrenaline Increases heart rate
Which of the following statements regarding glucagon is false?
(c) Glucagon increases blood sugar level. It is secreted by \(\alpha\)-cells of islets of Langerhans of pancreas (heterocrine gland).
Select the correct matching of a hormone, its source and function.
\(
\begin{array}{|c|c|c|c|}
\hline & \text { Hormone } & \text { Source } & \text { Function } \\
\hline \text { (a) } & \text { Vasopressin } & \text { Posterior pituitary } & \begin{array}{l}
\text { Increases loss of water through } \\
\text { urine }
\end{array} \\
\hline \text { (b) } & \begin{array}{l}
\text { Norepi- } \\
\text { nephrine }
\end{array} & \text { Adrenal medulla } & \begin{array}{l}
\text { Increases heart beat, rate of } \\
\text { respiration and alertness }
\end{array} \\
\hline \text { (c) } & \text { Glucagon } & \begin{array}{l}
\text { Beta-cells of islets } \\
\text { of Langerhans }
\end{array} & \text { Stimulates glycogenolysis } \\
\hline \text { (d) } & \text { Prolactin } & \text { Posterior pituitary } & \begin{array}{l}
\text { Regulates growth of mammary } \\
\text { glands and milk formation in } \\
\text { females }
\end{array} \\
\hline
\end{array}
\)
(b) Norepinephrine is secreted by the adrenal medulla and it increases heart beat, rate of respiration and alertness.Vasopressin increases reabsorption of water from the nephrons of the kidney, thereby, decreases loss of water through urine. Glucagon is secreted by \(\alpha\)-cells of islets of Langerhans. Prolactin is secreted from anterior pituitary.
Which of the following hormone is synthesised in both the brain and endocrine glands?
(d) Somatostatin is an inhibitory hormone which is secreted by hypothalamus in the brain and pancreas. Somatostatin from hypothalamus inhibits the secretion of growth hormone from the anterior lobe of pituitary. Somatostatin from pancreas inhibits the release of other hormones from pancreas like insulin and glucagon.
Select the option that correctly identifies A to E in the given flow chart.
\(
\begin{array}{|c|c|c|c|c|c|}
\hline & A & B & C & D & \text { E } \\
\hline \text { (a) } & \alpha & \beta & \text { Glucagon } & \text { Hyperglycaemia } & \text { Hypoglycaemia } \\
\hline \text { (b) } & \beta & \alpha & \text { Cortisol } & \text { Hypoglycaemia } & \text { Hyperglycaemia } \\
\hline \text { (c) } & \beta & \alpha & \text { Cortisol } & \text { Hyperglycaemia } & \text { Hypoglycaemia } \\
\hline \text { (d) } & \beta & \alpha & \text { Glucagon } & \text { Hypoglycaemia } & \text { Hyperglycaemia } \\
\hline
\end{array}
\)
Which one of the following is not the function of insulin?
(c) Insulin converts glucose into glycogen in the liver and muscles.
Select the mismatched pair from the following.
(a) Gluconeogenesis is the process of synthesis of glucose from non-carbohydrate sources such as fat and protein. Insulin promotes glycogenesis, i.e., it enables the liver and muscles to convert glucose into glycogen and to store it. It also enables the tissues to take up and use glucose as a source of energy. This lowers the blood-glucose level.
Which of the following is not a characteristic of insulin?
(a) Insulin hormone produced by beta cells of the pancreas, plays a major role in the regulation of glucose homeostasis. It stimulates the conversion of glucose to glycogen, i.e., glycogenesis. Gluconeogenesis is stimulated by glucagon.
A patient of diabetes mellitus excretes glucose in urine even when he is kept on a carbohydrate free diet. It is because
(a) In diabetes mellitus, a patient is unable to produce or utilise insulin hormone. This hormone helps in maintaining the level of glucose in the blood by converting extra glucose into glycogen. Thus, in diabetes mellitus, body of the patient becomes incapable to store glucose in the form of glycogen. Therefore, he starts excreting glucose in the urine. A patient kept on carbohydrate free diet is excreting glucose in the urine, because high level of glucose in the blood not only depends on dietary carbohydrates but also on glycogenolysis (breakdown of glycogen into glucose in the liver) and gluconeogenesis (breakdown of fats into glucose in adipose tissues).
Given below are four statements ( A – D) each with one or two blanks. Select the option which correctly fills up the blanks in any two statements.
(A) Thymus secretes (i) which help in differentiation of (ii).
(B) The adrenal medulla secretes (i) which stimulates the breakdown of (ii) to increase the blood glucose concentration during emergency situations.
(C) The Leydig’s cells or (i) present in the intertubular spaces in testis, produce a group of hormones called (ii).
(D) Thyroid gland secretes (i) and triiodothyronine which contain (ii).
Which one of the following statements is incorrect?
(b) Androgens are produced by testes and in small amounts by adrenal cortex.
Read the given statements that define the functions of a particular hormone.
(i) Regulates the development, maturation and functions of epididymis, vas deferens, seminal vesicle, prostate gland, urethra, etc.
(ii) Stimulates muscular growth of facial and axillary hair, aggressiveness, low pitch of voice, etc.
(iii) Stimulates spermatogenesis.
(iv) Act on CNS and sexual behaviour (libido).
(v) Produce anabolic (synthetic) effect on protein and carbohydrate metabolism.
(vi) The Leydig’s cells/interstitial cells (present in intertubular space) secrete this hormone under the influence of \(\mathrm{LH}\).
Which of the following hormones is referred to here?
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|l|l|l|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { Testis } & \text { (i) } & \text { Pigmentation } \\
\hline \text { B. } & \text { Ovaries } & \text { (ii) } & \text { Atrophies in adult } \\
\hline \text { C. } & \text { Thymus } & \text { (iii) } & \text { Estrogen } \\
\hline \text { D. } & \text { Melanin } & \text { (iv) } & \text { Testosterone } \\
\hline
\end{array}
\)
Given below is an incomplete table about certain hormones, their source glands and one major effect of each on the body in humans. Select the option that correctly fills the blanks A, B and C.
\(
\begin{array}{|l|l|l|}
\hline \multicolumn{1}{|c|}{\text { Glands }} & \text { Secretion } & \multicolumn{1}{|c|}{\text { Effect on body }} \\
\hline \text { A } & \text { Estrogen } & \begin{array}{l}
\text { Maintenance of } \\
\text { secondary sexual } \\
\text { characters }
\end{array} \\
\hline \begin{array}{l}
\text { Alpha cells of Islets } \\
\text { of Langerhans }
\end{array} & \text { B } & \begin{array}{l}
\text { Raises blood sugar } \\
\text { level }
\end{array} \\
\hline \text { Anterior pituitary } & \text { C } & \begin{array}{l}
\text { Oversecretion } \\
\text { leads to gigantism }
\end{array} \\
\hline
\end{array}
\)
\(
\begin{array}{|l|l|l|l|}
\hline & A & B & C \\
\hline \text { (a) } & \text { Placenta } & \text { Glucagon } & \text { Calcitonin } \\
\hline \text { (b) } & \text { Ovary } & \text { Glucagon } & \text { Growth hormone } \\
\hline \text { (c) } & \text { Placenta } & \text { Insulin } & \text { Vasopressin } \\
\hline \text { (d) } & \text { Ovary } & \text { Insulin } & \text { Calcitonin } \\
\hline
\end{array}
\)
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|l|l|c|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { Hypothalamus } & \text { (i) } & \text { Relaxin } \\
\hline \text { B. } & \text { Anterior pituitary } & \text { (ii) } & \text { Progesterone } \\
\hline \text { C. } & \text { Testis } & \text { (iii) } & \text { FSH and LH } \\
\hline \text { D. } & \text { Ovary } & \text { (iv) } & \text { Androgen } \\
\hline & & \text { (v) } & \begin{array}{l}
\text { Gonadotropin } \\
\text { releasing hormone }
\end{array} \\
\hline
\end{array}
\)
Which one of the following pairs is incorrectly matched?
(a) Glucagon increases blood sugar level. It is secreted by \(\alpha\)-cells of islets of Langerhans of pancreas (heterocrine gland).
Which of the following hormones is necessary for the development of secondary sexual characters in human beings?
(d) Estrogen, secreted by ovaries in females, stimulates the development of secondary sexual characters during puberty and maintains them through the reproductive years of adult life in females. Testosterone is produced by testes in males. It stimulates the development of male secondary sexual characters like beard, moustache, etc.
Match the source gland with its respective hormone and function and select the correct option.
\(
\begin{array}{|l|l|l|l|}
\hline & \text { Source gland } & \text { Hormone } & \text { Function } \\
\hline \text { (a) } & \begin{array}{l}
\text { Anterior } \\
\text { pituitary }
\end{array} & \text { Oxytocin } & \begin{array}{l}
\text { Contraction of uterus muscles during child } \\
\text { birth }
\end{array} \\
\hline \text { (b) } & \begin{array}{l}
\text { Posterior } \\
\text { pituitary }
\end{array} & \text { Vasopressin } & \begin{array}{l}
\text { Stimulates reabsorption of water in the } \\
\text { distal tubules in the nephron }
\end{array} \\
\hline \text { (c) } & \begin{array}{l}
\text { Corpus } \\
\text { luteum }
\end{array} & \text { Testosterone } & \text { Supports pregnancy } \\
\hline \text { (d) } & \text { Thyroid } & \text { Thyroxine } & \text { Regulates blood calcium level } \\
\hline
\end{array}
\)
(b) Oxytocin is released by posterior pituitary. Corpus luteum secretes progesterone. Calcitonin released by thyroid gland regulates blood calcium level.
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|c|l|c|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { Oxytocin } & \text { (i) } & \text { Stimulates ovulation } \\
\hline \text { B. } & \text { Prolactin } & \text { (ii) } & \begin{array}{l}
\text { Implantation and } \\
\text { maintenance of pregnancy }
\end{array} \\
\hline \text { C. } & \begin{array}{l}
\text { Luteinising } \\
\text { hormone }
\end{array} & \text { (iii) } & \begin{array}{l}
\text { Milk production in } \\
\text { mammary glands }
\end{array} \\
\hline \text { D. } & \text { Progesterone } & \text { (iv) } & \begin{array}{l}
\text { Uterine contraction during } \\
\text { labour }
\end{array} \\
\hline & & \text { (v) } & \begin{array}{l}
\text { Reabsorption of water by } \\
\text { nephrons }
\end{array} \\
\hline
\end{array}
\)
Low level of progesterone and estrogen in blood stimulate
(a) When secretion of hormones is under the control of factors or other hormones, it is called the feedback control. If the level of progesterone and estrogen is low in the blood, it stimulates the hypothalamus to secrete more FSH-RH which results in increased production of FSH from anterior pituitary which in turn stimulates the increased secretion of estrogen and progesterone from ovary.
Match column I with column II and select the correct option from the given codes.
\(
\begin{array}{|l|l|c|l|}
\hline & \text { Column I } & & \text { Column II } \\
\hline \text { A. } & \text { ANF } & \text { (i) } & \text { Regulates blood calcium levels } \\
\hline \text { B. } & \text { MSH } & \text { (ii) } & \text { Decreases blood pressure } \\
\hline \text { C. } & \text { GIP } & \text { (iii) } & \text { Pigmentation } \\
\hline \text { D. } & \text { CT } & \text { (iv) } & \text { Inhibits gastric secretion } \\
\hline
\end{array}
\)
Which part of body secretes the hormone secretin?
(d) Secretin hormone is secreted by the intestinal mucosa of duodenum and jejunum.
Select the correctly matched pair.
(d) Pineal gland – Influences menstrual cycle Corpus luteum – Secretes progesterone Interstitial cells – Secrete androgens Cholecystokinin – Stimulates pancreatic enzyme secretion
Read the given paragraph and select the option that correctly fills the blanks in it.
Hormones produce their effect on target tissue by binding to specific A called hormone receptors located in the target tissues only. Water soluble hormones usually need B receptors that generate C messengers for regulating cellular metabolism. D soluble hormones can pass through cell membranes and bind to E receptors, mostly nuclear receptors. The hormone receptor complex enters the nucleus and mostly regulates gene expression or chromosome function by the interaction of the hormone-receptor complex with the genome.
\(
\begin{array}{|l|l|l|l|l|l|}
\hline & \text { A } & \text { B } & \text { C } & \text { D } & \text { E } \\
\hline \text { (a) } & \text { proteins } & \text { membrane bound } & \text { secondary } & \text { lipid } & \text { intra cellular } \\
\hline \text { (b) } & \text { lipids } & \text { membrane bound } & \text { secondary } & \text { water } & \text { intra cellular } \\
\hline \text { (c) } & \text { proteins } & \text { membrane bound } & \text { secondary } & \text { lipid } & \text { extra cellular } \\
\hline \text { (d) } & \text { proteins } & \text { membrane bou } & \text { primary } & \text { lipid } & \text { intra cellular } \\
\hline
\end{array}
\)
The given diagram represents the mechanism of action for two categories of hormones. Which of the following options correctly identifies the labels A to I?
Refer to the given diagrammatic representation of the mechanism of action of a protein hormone.
In which of the following options correct labelling of A, B and C is given?
\(
\begin{array}{|l|l|l|l|}
\hline & \text { A } & \text { B } & \text { C } \\
\hline \text { (a) } & \begin{array}{l}
\text { Generation of second } \\
\text { messenger }
\end{array} & \begin{array}{l}
\text { Physiological } \\
\text { responses }
\end{array} & \text { Biochemical responses } \\
\hline \text { (b) } & \text { Activation of genes } & \begin{array}{l}
\text { Biochemical } \\
\text { responses }
\end{array} & \begin{array}{l}
\text { Generation of second } \\
\text { messenger }
\end{array} \\
\hline \text { (c) } & \begin{array}{l}
\text { Generation of second } \\
\text { messenger }
\end{array} & \begin{array}{l}
\text { Biochemical } \\
\text { responses }
\end{array} & \text { Physiological responses } \\
\hline \text { (d) } & \text { Biochemical responses } & \text { Activation of genes } & \text { Physiological responses } \\
\hline
\end{array}
\)
What is correct to say about the hormone action in humans?
(c) Mechanism of hormone action is not the same in all categories of hormones. These hormones bind with the specific receptors located in their target tissues. Hormone receptor is of two types: membrane bound receptor and intracellular receptor. FSH is a proteinaceous hormone, has large molecular weight and is insoluble in lipids, therefore, it cannot enter the target cell. Thus, it binds with the membrane bound receptor present on ovarian cell membrane.
According to the accepted concept of hormone action, if receptor molecules are removed from target organs, then the target organ will
(b) Hormones recognise target organs by the presence of specific receptor molecules on the plasma membrane of target organs. If these receptor molecules are removed then a hormone will be unable to give any response.
Which one of the following is proteinaceous in chemical nature?
(b) Glucagon secreted by \(\alpha\)-cells of islet of Langerhans and proteinaceous in nature.
Insulin is a/an
(b) Insulin is a protein hormone.
Insulin receptors are
All hypophysiotropic hormones are peptides except
(d) Prolactin release inhibiting hormone is an amino acid derivative hormone produced in the hypothalamus.
Which of the following hormones is a steroid?
The steroids are organic compounds involved in biological processes. Steroid hormones are generally synthesized from cholesterol in gonads and adrenal glands. They are basically lipids. For example, estrogen, progesterone, testosterone, etc.
Thus, the correct answer is ‘Estrogen.’
Hormones of which of the following endocrine glands lacks peptides, amines and sulphur?
(c) Hormones of testes are steroid in nature. They are derived from cholesterol.
Which of the following hormones is not a polypeptide?
(d) Thyroxine is an iodothyronine.
The given table enlists various hormones and their chemical nature. Select the option which completes the table.
\(
\begin{array}{|c|c|}
\hline \text { Hormone } & \text { Chemical composition } \\
\hline \text { (i) } & \text { Peptide } \\
\hline \text { Testosterone } & \text { (ii) } \\
\hline \text { Thyroxine } & \text { (iii) } \\
\hline \text { (iv) } & \text { Amino-acid derivative } \\
\hline
\end{array}
\)
\(
\begin{array}{|l|l|l|l|l|}
\hline & \text { (i) } & \text { (ii) } & \text { (iii) } & \text { (iv) } \\
\hline \text { (a) } & \text { Cortisol } & \text { Steroid } & \text { Polypeptide } & \text { Estradiol } \\
\hline \text { (b) } & \text { Oxytocin } & \text { Protein } & \text { lodothyronine } & \text { Epinephrine } \\
\hline \text { (c) } & \text { Cortisol } & \text { Protein } & \text { Amine } & \text { Estradiol } \\
\hline \text { (d) } & \text { Oxytocin } & \text { Steroid } & \text { lodothyronine } & \text { Epinephrine } \\
\hline
\end{array}
\)
Which one of the following hormones never reaches to cytoplasm?
(b) FSH is a proteinaceous hormone. It does not enter its target cells, thus, it never reaches to cytoplasm. Instead, it binds to the receptor present on the cell membrane and activates a membrane bound enzyme that causes conversion of ATP to CAMP. This then alters the activities of enzymes in the cytoplasm.
The signal transduction of steroid hormone across cell is through
(a) Steroid hormones, being hydrophobic molecules, diffuse freely into all cells and act within the cell. Steroid hormones enter the cytoplasm of a target cell and bind with specific receptor proteins (mobile). Hormone-receptor complex then diffuses into nucleus and activates specific genes to form a new protein. This protein carries out the specific response for a particular steroid hormone.
Estrogen and testosterone are steroid hormones, and most likely bind to
The correct option is d.
Explanation of the correct option:
1. The group of chemical substances known as steroids includes steroid hormones.
2. The nature of steroid hormones is mostly lipophilic.
3. This is due to the fact that lipids in the cell membrane do not prevent lipophilic substances from entering the cell.
4. Steroid hormones therefore readily permeate through the cell membrane for this reason.
5. The steroid hormones either bind to cytoplasmic or nucleic receptors as they enter the cell.
6. As steroid hormones, estrogen and testosterone are most likely coupled to cytoplasmic receptors.
Refer to the given figure of pituitary gland and select the correct option for the question that follows.
What will be the effect if part C is removed?
(b) In the given figure, C represents posterior pituitary. Posterior pituitary stores and releases two hormones i.e., oxytocin and ADH which are actually synthesised by the hypothalamus and are transported axonally to neurohypophysis or posterior pituitary.
The given figure shows _____.
(a) Beta cells of pancreas produce insulin. It promotes protein synthesis in tissues from amino acids and reduces catabolism of proteins. It increases the synthesis of fats in the adipose tissue from fatty acids and reduces the breakdown and oxidation of fats. Insulin decreases the level of glucose in the blood. It acts by increasing the rate at which glucose is transported out of the blood and into cells and by stimulating muscle cells to take up sugar from the blood and convert it to glycogen.
Pancreas has two types of cells namely islets of Langerhans and acinar cells. In the early years of research on diabetes, extract of this gland was tested on diabetic patients. Results are tabulated below:
\(
\begin{array}{|l|l|l|}
\hline & & \begin{array}{l}
\text { Reduction in blood } \\
\text { sugar level }
\end{array} \\
\hline \text { A. } & \text { Extract of pancreas } & – \\
\hline \text { B. } & \text { Islet cell extract } & + \\
\hline \text { C. } & \text { Acinar cell extract } & – \\
\hline
\end{array}
\)
The correct interpretation is that
(d) The result shows that the extract of pancreas is ineffective to reduce blood sugar level. The extract contains secretions of both exocrine and endocrine parts i.e., acinar cells and islet of Langerhans respectively. Since extract of endocrine part which is islet of Langerhans is individually capable of reducing sugar level, this shows that some factors from acinar cells are preventing antidiabetic factor to function.
Read the following paragraph depicting the interplay of two hormones in women $X$ and $Y$ and select the correct option.
A woman \(X\) exhibits high levels of FSH (Follicle stimulating hormone) but low levels of estrogen in blood. Another woman \(Y\) exhibits high levels of both FSH and estrogen in the blood.
(b) Estrogen negative feedback in females is a very good example of negative feedback loop. Negative feedback loop is a self regulating system where increased output from the system inhibits further production. The hypothalamus produces gonadotropin releasing hormone GnRH which signals pituitary to produce follicle stimulating hormone (FSH). FSH signals the ovaries to produce estrogen. High levels of estrogen then inhibit the production of GnRH from hypothalamus which signals pituitary to make less FSH and in turn less estrogen.
Which of the following are influenced by the activity of PTH?
The option containing all correct answers is
I. Kidney
II. Bone
III. Muscle
IV. Intestine
V. Heart
(a) Functions of parathyroid hormone (PTH) are :
(i) Regulate calcium and phosphate level in blood.
(ii) Increase rate of calcium absorption from intestine in children to elevate blood level of calcium.
(iii) Start bone dissolution (osteoclastic action) and stimulates excretion of calcium in blood.
(iv) It affects the growth of bones, membrane permeability, nerve functioning and muscular activity of the body.
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